Contents
SECTION I Structures & Functions of Proteins & Enzymes
1 Biochemistry & Medicine 1
Victor W. Rodwell, PhD, & Robert K. Murray, MD, PhD
2 Water & pH 6
Peter J. Kennelly, PhD & Victor W. Rodwell, PhD
3 Amino Acids & Peptides 14
Peter J. Kennelly, PhD & Victor W. Rodwell, PhD
4 Proteins: Determination of Primary Structure 23
Peter J. Kennelly, PhD & Victor W. Rodwell, PhD
5 Proteins: Higher Orders of Structure 33
Peter J. Kennelly, PhD & Victor W. Rodwell, PhD
SECTION II Enzymes: Kinetics, Mechanism, Regulation, & Role of Transition Metals 47
6 Proteins: Myoglobin & Hemoglobin 47
Peter J. Kennelly, PhD & Victor W. Rodwell, PhD
7 Enzymes: Mechanism of Action 56
Peter J. Kennelly, PhD & Victor W. Rodwell, PhD
8 Enzymes: Kinetics 68
Victor W. Rodwell, PhD
9 Enzymes: Regulation of Activities 82
Peter J. Kennelly, PhD & Victor W. Rodwell, PhD
10 The Biochemical Roles of Transition Metals 92
Peter J. Kennelly, PhD
SECTION III Bioenergetics 105
11 Bioenergetics: The Role of ATP 105
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
12 Biologic Oxidation 111
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
13 The Respiratory Chain & Oxidative Phosphorylation 117
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
SECTION IV Metabolism of Carbohydrates 129
14 Overview of Metabolism & the Provision of Metabolic Fuels 129
David A. Bender, PhD & Peter A. Mayes, PhD, DSc
15 Carbohydrates of Physiological Significance 141
David A. Bender, PhD & Peter A. Mayes, PhD, DSc
16 The Citric Acid Cycle: The Central Pathway of Carbohydrate, Lipid, & Amino Acid Metabolism 150
David A. Bender, PhD & Peter A. Mayes, PhD, DSc 17 Glycolysis & the Oxidation of Pyruvate 157
David A. Bender, PhD & Peter A. Mayes, PhD, DSc
18 Metabolism of Glycogen 164
David A. Bender, PhD & Peter A. Mayes, PhD, DSc
19 Gluconeogenesis & the Control of
Blood Glucose 172
David A. Bender, PhD & Peter A. Mayes, PhD, DSc
20 The Pentose Phosphate Pathway & Other Pathways of Hexose Metabolism 182
David A. Bender, PhD & Peter A. Mayes, PhD, DSc
SECTION V Metabolism of Lipids 195
21 Lipids of Physiologic Significance 195
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
22 Oxidation of Fatty Acids: Ketogenesis 207
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
23 Biosynthesis of Fatty Acids &
Eicosanoids 216
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
24 Metabolism of Acylglycerols & Sphingolipids 229
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
25 Lipid Transport & Storage 236
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
26 Cholesterol Synthesis, Transport, & Excretion 249
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
SECTION VI Metabolism of Proteins & Amino Acids 263
27 Biosynthesis of the Nutritionally Nonessential Amino Acids 263
Victor W. Rodwell, PhD
28 Catabolism of Proteins & of Amino Acid Nitrogen 269
Victor W. Rodwell, PhD
29 Catabolism of the Carbon Skeletons of
Amino Acids 280
Victor W. Rodwell, PhD
30 Conversion of Amino Acids to Specialized Products 296
Victor W. Rodwell, PhD
31 Porphyrins & Bile Pigments 305
Victor W. Rodwell, PhD & Robert K. Murray, MD, PhD
SECTION VII Structure, Function, & Replication of Informational Macromolecules 319
32 Nucleotides 319
Victor W. Rodwell, PhD
33 Metabolism of Purine & Pyrimidine Nucleotides 327
Victor W. Rodwell, PhD
34 Nucleic Acid Structure & Function 338
P. Anthony Weil, PhD
35 DNA Organization, Replication, &
Repair 350
P. Anthony Weil, PhD
36 RNA Synthesis, Processing, &
Modification 374
P. Anthony Weil, PhD
37 Protein Synthesis & the Genetic Code 393
P. Anthony Weil, PhD
38 Regulation of Gene Expression 409
P. Anthony Weil, PhD
39 Molecular Genetics, Recombinant DNA, & Genomic Technology 432
P. Anthony Weil, PhD
SECTION VIII Biochemistry of Extracellular & Intracellular Communication 459
40 Membranes: Structure &
Function 459
P. Anthony Weil, PhD
41 The Diversity of the Endocrine
System 480
P. Anthony Weil, PhD
42 Hormone Action & Signal
Transduction 500
P. Anthony Weil, PhD
SECTION IX Special Topics (A) 519
43 Nutrition, Digestion, &
Absorption 519
David A. Bender, PhD & Peter A. Mayes, PhD, DSc
44 Micronutrients: Vitamins &
Minerals 527
David A. Bender, PhD
45 Free Radicals & Antioxidant
Nutrients 541
David A. Bender, PhD
46 Glycoproteins 546
David A. Bender, PhD & Robert K. Murray, MD, PhD
47 Metabolism of Xenobiotics 556
David A. Bender, PhD & Robert K. Murray, MD, PhD
48 Clinical Biochemistry 560
David A. Bender, PhD & Robert K. Murray, MD, PhD
SECTION X Special Topics (B) 573
49 Intracellular Traffic & Sorting of Proteins 573
Kathleen M. Botham, PhD, DSc & Robert K. Murray, MD, PhD
50 The Extracellular Matrix 592
Kathleen M. Botham, PhD, DSc & Robert K. Murray, MD, PhD
51 Muscle & the Cytoskeleton 611
Peter J. Kennelly, PhD and Robert K. Murray, MD, PhD
52 Plasma Proteins & Immunoglobulins 627
Peter J. Kennelly, PhD, Robert K. Murray, MD, PhD,
Molly Jacob, MBBS, MD, PhD & Joe Varghese, MBBS, MD
53 Red Blood Cells 646
Peter J. Kennelly, PhD & Robert K. Murray, MD, PhD
54 White Blood Cells 656
Peter J. Kennelly, PhD & Robert K. Murray, MD, PhD
SECTION XI Special Topics (C) 669
55 Hemostasis & Thrombosis 669
Peter L. Gross, MD, MSc, FRCP(C),
P. Anthony Weil, PhD & Margaret L. Rand, PhD
56 Cancer: An Overview 681
Molly Jacob, MD, PhD, Joe Varghese, MBBS, MD &
P. Anthony Weil, PhD
57 The Biochemistry of Aging 707
Peter J. Kennelly, PhD
58 Biochemical Case Histories 719
David A. Bender, PhD
The Answer Bank 731
Index 735
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