Contents

p a r t I
BASIC PRINCIPLES 1

1. Introduction 1
2. Pharmacodynamics 16
3. Pharmacokinetics 26
4. Drug Metabolism 35
5. Pharmacogenomics 41
   p a r t II
   AUTONOMIC DRUGS 47
6. Introduction to Autonomic Pharmacology 47
7. Cholinoceptor-Activating
   & Cholinesterase-Inhibiting Drugs 60
8. Cholinoceptor Blockers & Cholinesterase
   Regenerators 69
9. Sympathomimetics 76
10. Adrenoceptor Blockers 85
    p a r t III
    CARDIOVASCULAR DRUGS 93
11. Drugs Used in Hypertension 93
12. Drugs Used in the Treatment of Angina
    Pectoris 103
13. Drugs Used in Heart Failure 112
14. Antiarrhythmic Drugs 121
15. Diuretics & Other Drugs That Act on the
    Kidney 132

p a r t IV
DRUGS WITH IMPORTANT ACTIONS
ON SMOOTH MUSCLE 143

16. Histamine, Serotonin, & the Ergot
    Alkaloids 143
17. Vasoactive Peptides 152
18. Prostaglandins & Other Eicosanoids 158
19. Nitric Oxide, Donors, & Inhibitors 165
20. Drugs Used in Asthma & Chronic
    Obstructive Pulmonary Disease 169
    p a r t V
    DRUGS THAT ACT IN THE CENTRAL
    NERVOUS SYSTEM 179
21. Introduction to CNS Pharmacology 179
22. Sedative-Hypnotic Drugs 186
23. Alcohols 194
24. Antiseizure Drugs 201
25. General Anesthetics 208
26. Local Anesthetics 216
27. Skeletal Muscle Relaxants 221
28. Drugs Used in Parkinsonism & Other
    Movement Disorders 229
29. Antipsychotic Agents & Lithium 236
30. Antidepressants 244
31. Opioid Analgesics & Antagonists 252
32. Drugs of Abuse 260

p a r t VI
DRUGS WITH IMPORTANT ACTIONS
ON BLOOD, INFLAMMATION,
& GOUT 267

33. Agents Used in Cytopenias; Hematopoietic
    Growth Factors 267
34. Drugs Used in Coagulation Disorders 276
35. Agents Used in Dyslipidemia 288
36. NSAIDs, Acetaminophen, & Drugs Used in
    Rheumatoid Arthritis & Gout 296
    p a r t VII
    ENDOCRINE DRUGS 307
37. Hypothalamic & Pituitary Hormones 307
38. Thyroid & Antithyroid Drugs 316
39. Corticosteroids & Antagonists 322
40. Gonadal Hormones & Inhibitors 329
41. Pancreatic Hormones, Antidiabetic Agents,
    & Glucagon 340
42. Drugs That Affect Bone Mineral
    Homeostasis 349
    p a r t VIII
    CHEMOTHERAPEUTIC DRUGS 359
43. Beta-Lactam Antibiotics & Other Cell Wall
    Synthesis Inhibitors 360
44. Chloramphenicol, Tetracyclines,
    Macrolides, Clindamycin, Streptogramins,
    & Linezolid 369
45. Aminoglycosides 377
46. Sulfonamides, Trimethoprim, &
    Fluoroquinolones 382

47. Antimycobacterial Drugs 389
48. Antifungal Agents 395
49. Antiviral Chemotherapy & Prophylaxis 402
50. Miscellaneous Antimicrobial Agents
    & Urinary Antiseptics 414
51. Clinical Use of Antimicrobials 420
52. Antiprotozoal Drugs 426
53. Antihelminthic Drugs 434
54. Cancer Chemotherapy 440
55. Immunopharmacology 452
    p a r t IX
    TOXICOLOGY 463
56. Environmental & Occupational
    Toxicology 463
57. Heavy Metals 469
58. Management of the Poisoned Patient 475
    p a r t X
    SPECIAL TOPICS 483
59. Drugs Used in Gastrointestinal
    Disorders 483
60. Dietary Supplements & Herbal
    Medications 492
61. Drug Interactions 497
    Appendix I. Strategies for Improving Test
    Performance 503
    Appendix II. Key Words for Key Drugs 506
    Appendix III. Examination 1 518
    Appendix IV. Examination 2 534
    Index 549

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