Contents

  1 Histology & Its Methods of Study 1 Preparation of Tissues for Study 1
Light Microscopy 4 Electron Microscopy 8 Autoradiography 9 Cell & Tissue Culture 10 Enzyme Histochemistry 10
Visualizing Specific Molecules 10
Interpretation of Structures in Tissue Sections 14 Summary of Key Points 15 Assess Your Knowledge 16
2 The Cytoplasm 17
Cell Differentiation 17
The Plasma Membrane 17
Cytoplasmic Organelles 27
The Cytoskeleton 42
Inclusions 47
Summary of Key Points 51
Assess Your Knowledge 52
3 The Nucleus 53
Components of the Nucleus 53
The Cell Cycle 58 Mitosis 61
Stem Cells & Tissue Renewal 65
Meiosis 65 Apoptosis 67
Summary of Key Points 69
Assess Your Knowledge 70
4 Epithelial Tissue 71
Characteristic Features of Epithelial Cells 72 Specializations of the Apical Cell Surface 77
Types of Epithelia 80
Transport Across Epithelia 88
Renewal of Epithelial Cells 88
Summary of Key Points 90
Assess Your Knowledge 93
  5 Connective Tissue 96
Cells of Connective Tissue 96
Fibers 103
Ground Substance 111
Types of Connective Tissue 114
Summary of Key Points 119
Assess Your Knowledge 120
6 Adipose Tissue 122
White Adipose Tissue 122
Brown Adipose Tissue 126
Summary of Key Points 127
Assess Your Knowledge 128
7 Cartilage 129
Hyaline Cartilage 129
Elastic Cartilage 133
Fibrocartilage 134
Cartilage Formation, Growth, & Repair 134 Summary of Key Points 136
Assess Your Knowledge 136
8 Bone 138
Bone Cells 138 Bone Matrix 143
Periosteum & Endosteum 143
Types of Bone 143 Osteogenesis 148
Bone Remodeling & Repair 152
Metabolic Role of Bone 153
Joints 155
Summary of Key Points 158
Assess Your Knowledge 159
9 Nerve Tissue & the Nervous System 161 Development of Nerve Tissue 161
Neurons 163
Glial Cells & Neuronal Activity 168
Central Nervous System 175                 Peripheral Nervous System 182
Neural Plasticity & Regeneration 187
Summary of Key Points 190
Assess Your Knowledge 191
  10 Muscle Tissue 193
Skeletal Muscle 193
Cardiac Muscle 207
Smooth Muscle 208
Regeneration of Muscle Tissue 213
Summary of Key Points 213
Assess Your Knowledge 214
11 The Circulatory System 215
Heart 215
Tissues of the Vascular Wall 219
Vasculature 220
Lymphatic Vascular System 231
Summary of Key Points 235 Assess Your Knowledge 235
12 Blood 237
Composition of Plasma 237
Blood Cells 239
Summary of Key Points 250
Assess Your Knowledge 252
13 Hemopoiesis 254
Stem Cells, Growth Factors, & Differentiation 254 Bone Marrow 255 Maturation of Erythrocytes 258 Maturation of Granulocytes 260 Maturation of Agranulocytes 263 Origin of Platelets 263 Summary of Key Points 265 Assess Your Knowledge 265
14 The Immune System & Lymphoid Organs 267 Innate & Adaptive Immunity 267
Cytokines 269
Antigens & Antibodies 270
Antigen Presentation 271
Cells of Adaptive Immunity 273
Thymus 276
Mucosa-Associated Lymphoid Tissue 281
Lymph Nodes 282
Spleen 286
Summary of Key Points 293
Assess Your Knowledge 294
15 Digestive Tract 295
General Structure of the Digestive Tract 295
Oral Cavity 298 Esophagus 305 Stomach 307
Small Intestine 314 Large Intestine 318
Summary of Key Points 326
Assess Your Knowledge 327
16 Organs Associated with the Digestive Tract 329
Salivary Glands 329
Pancreas 332 Liver 335
Biliary Tract & Gallbladder 345
Summary of Key Points 346 Assess Your Knowledge 348
17 The Respiratory System 349
Nasal Cavities 349
Pharynx 352 Larynx 352 Trachea 354
Bronchial Tree & Lung 354
Lung Vasculature & Nerves 366
Pleural Membranes 368
Respiratory Movements 368
Summary of Key Points 369 Assess Your Knowledge 369
18 Skin 371
Epidermis 372
Dermis 378
Subcutaneous Tissue 381
Sensory Receptors 381
Hair 383
Nails 384
Skin Glands 385
Skin Repair 388
Summary of Key Points 391
Assess Your Knowledge 391
19 The Urinary System 393
Kidneys 393
Blood Circulation 394
Renal Function: Filtration, Secretion, & Reabsorption 395
Ureters, Bladder, & Urethra 406
Summary of Key Points 411
Assess Your Knowledge 412
  20 Endocrine Glands 413
Pituitary Gland (Hypophysis) 413
Adrenal Glands 423 Pancreatic Islets 427
Diffuse Neuroendocrine System 429
Thyroid Gland 429 Parathyroid Glands 432
Pineal Gland 434 Summary of Key Points 437 Assess Your Knowledge 437
21 The Male Reproductive System 439
Testes 439 Intratesticular Ducts 449
Excretory Genital Ducts 450 Accessory Glands 451 Penis 456 Summary of Key Points 457
Assess Your Knowledge 459
  22 The Female Reproductive System 460 Ovaries 460
Uterine Tubes 470
Major Events of Fertilization 471
Uterus 471
Embryonic Implantation, Decidua, & the Placenta 478
Cervix 482
Vagina 483
External Genitalia 483
Mammary Glands 483
Summary of Key Points 488
Assess Your Knowledge 489
23 The Eye & Ear: Special Sense Organs 490
Eyes: The Photoreceptor System 490
Ears: The Vestibuloauditory System 509
Summary of Key Points 522
Assess Your Knowledge 522
APPENDIX 525 FIGURE CREDITS 527 INDEX 529

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