LEARNING OBJECTIVES
At the end of the session, the students should be able to:
• Discuss the drugs blocking the Neuro-muscular junction.
• Discuss the Drugs That Stimulate the Neuromuscular Junction
• Discuss the drugs that Stimulate the Muscle Fiber by Acetylcholine-
Like Action.
Drugs affecting Neuromuscular Junction
Drugs that Stimulate Muscle Fiber by Ach like action
•Carbachol
•Nicotine
•Methacholine
Drugs that inactivate Acetylcholinesterase
•Neostigmine
•Physostigmine
•Di-isopropyl fluorophosphate
Drugs that Block neurotransmission at NMJ
•Curariform drugs
•D-Tubocurarine
Examples of Chemical Agents and Diseases that Affect the Neuromuscular Junction
A: curare, a drug that blocks the gating action of acetylcholine on the acetylcholine channels by competing for
the acetylcholine receptor sites.
C: botulinum toxin, a bacterial poison that decreases the quantity
of acetylcholine release by the nerve terminals.
