At the end of the session, the students should be able to:

• Discuss the drugs blocking the Neuro-muscular junction.
• Discuss the Drugs That Stimulate the Neuromuscular Junction

• Discuss the drugs that Stimulate the Muscle Fiber by Acetylcholine-
Like Action.

Drugs affecting Neuromuscular Junction

Drugs that Stimulate Muscle Fiber by Ach like action


Drugs that inactivate Acetylcholinesterase

•Di-isopropyl fluorophosphate

Drugs that Block neurotransmission at NMJ

•Curariform drugs

Examples of Chemical Agents and Diseases that Affect the Neuromuscular Junction

A: curare, a drug that blocks the gating action of acetylcholine on the acetylcholine channels by competing for
the acetylcholine receptor sites.
C: botulinum toxin, a bacterial poison that decreases the quantity
of acetylcholine release by the nerve terminals.

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