THE PHARMACOLOGICAL BASIS OF THERAPEUTICS THIRTEENTH EDITION pdf book free download

Contents

Section I
General Principles 1

1. Drug Invention and the Pharmaceutical Industry……………………….. 3
2. Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination……………………………….. 13
3. Pharmacodynamics: Molecular Mechanisms of Drug Action…….. 31
4. Drug Toxicity and Poisoning……………………………………………………… 55
5. Membrane Transporters and Drug Response…………………………….. 65
6. Drug Metabolism………………………………………………………………………. 85
7. Pharmacogenetics……………………………………………………………………. 101

Section II
Neuropharmacology 113

8. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems………………… 115
9. Muscarinic Receptor Agonists and Antagonists……………………….. 149
10. Anticholinesterase Agents………………………………………………………… 163
11. Nicotine and Agents Acting at the Neuromuscular Junction and Autonomic Ganglia…………….. 177
12. Adrenergic Agonists and Antagonists………………………………………. 191
13. 5-Hydroxytryptamine (Serotonin) and Dopamine…………………… 225
14. Neurotransmission in the Central Nervous System………………….. 243
15. Drug Therapy of Depression and Anxiety Disorders………………… 267
16. Pharmacotherapy of Psychosis and Mania……………………………….. 279
17. Pharmacotherapy of the Epilepsies…………………………………………… 303
18. Treatment of Central Nervous System Degenerative Disorders………. 327
19. Hypnotics and Sedatives………………………………………………………….. 339
20. Opioids, Analgesia, and Pain Management………………………………. 355
21. General Anesthetics and Therapeutic Gases…………………………….. 387
22. Local Anesthetics…………………………………………………………………….. 405
23. Ethanol…………………………………………………………………………………….. 421
24. Drug Use Disorders and Addiction………………………………………….. 433

Section III
Modulation of Pulmonary, Renal, and Cardiovascular Function 443

25. Drugs Affecting Renal Excretory Function………………………………. 445
26. Renin and Angiotensin…………………………………………………………….. 471
27. Treatment of Ischemic Heart Disease……………………………………….. 489
28. Treatment of Hypertension………………………………………………………. 507
29. Therapy of Heart Failure………………………………………………………….. 527
30. Antiarrhythmic Drugs……………………………………………………………… 547
31. Treatment of Pulmonary Arterial Hypertension………………………. 573
32. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs………. 585
33. Drug Therapy for Dyslipidemias………………………………………………. 605

Section IV

Inflammation, Immunomodulation, and Hematopoiesis 619

34. Introduction to Immunity and Inflammation…………………………… 621
35. Immunosuppressants and Tolerogens………………………………………. 637
36. Immune Globulins and Vaccines……………………………………………… 655
37. Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor…………………. 673
38. Pharmacotherapy of Inflammation, Fever, Pain, and Gout……….. 685
39. Histamine, Bradykinin, and Their Antagonists………………………… 711
40. Pulmonary Pharmacology……………………………………………………….. 727
41. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins……. 751

Section V
Hormones and Hormone Antagonists 769

42. Introduction to Endocrinology: The Hypothalamic-Pituitary Axis…………….. 771
43. Thyroid and Antithyroid Drugs……………………………………………….. 787
44. Estrogens, Progestins, and the Female Reproductive Tract……….. 803
45. Androgens and the Male Reproductive Tract…………………………… 833
46. Adrenocorticotropic Hormone, Adrenal Steroids, and the Adrenal Cortex…………………. 845
47. Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia………….. 863
48. Agents Affecting Mineral Ion Homeostasis and Bone Turnover………………… 887

Section VI
Gastrointestinal Pharmacology 907

49. Pharmacotherapy for Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease…… 909
50. Gastrointestinal Motility and Water Flux, Emesis, and Biliary and Pancreatic Disease……. 921
51. Pharmacotherapy of Inflammatory Bowel Disease…………………… 945

Section VII
Chemotherapy of Infectious Diseases 955

52. General Principles of Antimicrobial Therapy…………………………… 957
53. Chemotherapy of Malaria………………………………………………………… 969
54. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections…. 987
55. Chemotherapy of Helminth Infections……………………………………1001
56. Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections….1011
57. Penicillins, Cephalosporins, and Other β-Lactam Antibiotics……1023
58. Aminoglycosides………….1039
59. Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents…….1049
60. Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosy……….1067
61. Antifungal Agents……..1087
62. Antiviral Agents (Nonretroviral)…………………………………………….1105
63. Treatment of Viral Hepatitis (HBV/HCV)………………………………1119
64. Antiretroviral Agents and Treatment of HIV Infection……………1137

Section VIII
Pharmacotherapy of Neoplastic Disease 1159

65. General Principles in the Pharmacotherapy of Cancer…………….1161
66. Cytotoxic Drugs……………………………………………………………………..1167
67. Pathway-Targeted Therapies: Monoclonal Antibodies, Protein Kinase Inhibitors, and Various Small Molecules……………………..1203
68. Hormones and Related Agents in the Therapy of Cancer………..1237

Section IX
Special Systems Pharmacology 1249

69. Ocular Pharmacology……………………………………………………………..1251
70. Dermatological Pharmacology………………………………………………..1271
71. Environmental Toxicology: Carcinogens and Heavy Metals……1297

Appendices
I. Principles of Prescription Order Writing and Patient Compliance……….1317
II. Design and Optimization of Dosage Regimens:
Pharmacokinetic Data…………………………………………………………….1325

Index 1379

General Principles
Chapter 1. Drug Invention and the Pharmaceutical
Industry / 3
Chapter 2. Pharmacokinetics: The Dynamics of Drug Absorption,
Distribution, Metabolism, and Elimination / 13
Chapter 3. Pharmacodynamics: Molecular Mechanisms of Drug Action / 31
Chapter 4. Drug Toxicity and Poisoning / 55
Chapter 5. Membrane Transporters and Drug Response / 65
Chapter 6. Drug Metabolism / 85
Chapter 7. Pharmacogenetics / 101

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