Transport of Oxygen Physiology Lecture PowerPoint SlidesTransport of Oxygen Physiology Lecture PowerPoint Slides

Learning Objectives:

  • At the end of the lecture, the students should be able to:
  • Explain the partial pressures oxygen and carbon dioxide in various parts of body
  • Explain the role f hemoglobin in oxygen transport
  • Discuss oxygen-hemoglobin dissociation curve and factors shifting it to right or left.


Oxygen at tissue level

  • Increasing blood flow increases the interstitial fluid PO2
  • Increasing tissue metabolism decreases the interstitial fluid PO2

Carbon dioxide at tissue level

Carbon dioxide

  • Increasing the blood flow decreases interstitial PCO2
  • Increasing metabolic activity increases interstitial PCO2

Transport of Oxygen

  • 3% of oxygen is transported in dissolved state in blood
  • 97% of oxygen is transported by hemoglobin
  • 30-100 times more due to hemoglobin

Oxygen Transport

  • When PO2 is high : O2 binds with hemoglobin
  • When PO2 is low: O2 is released from hemoglobin

Oxygen and hemoglobin

  • 1.34 ml of O2 in each gmof Hb
  • 15gms of Hbwill carry 20.1 ml of O2 / 100ml of blood
  • (if 100% saturated)
  • It is 19.4 ml / 100ml of blood (97% saturated)
  • 14.4 ml / 100ml of blood (75% saturated) (venous end of capillaries)

Effect of exercise on Oxygen transport

  • 15ml of oxygen is transported /100ml of blood during strenuous exercise
  • As the PO2 decreases from 40mmHg to as low as 15mmHg in interstitial fluid
  • There can be a total of 20 times increase in the oxygen transport

Utilization Coefficient

  • % of blood that gives up O2 as it passes through the tissue capillaries
  • Normal 25%
  • increase to 75-80%
  • Upper limit of Oxygen in Tissue = PO2 40mmHg
  • It occurs because it causes the oxygen release from the hemoglobin.
  • If PO2 is more Oxygen binds with Hemoglobin

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