Contents
Section I Structures & Functions of Proteins & Enzymes
- Biochemistry & Medicine 1
- Water & pH 6
- Amino Acids & Peptides 15
- Proteins: Determination of Primary Structure 25
- Proteins: Higher Orders of Structure 36
Section II Enzymes: Kinetics, Mechanism, Regulation, & Bioinformatics
- Proteins: Myoglobin & Hemoglobin 51
- Enzymes: Mechanism of Action 60
- Enzymes: Kinetics 73
- Enzymes: Regulation of Activities 87
- Bioinformatics & Computational Biology 97
Section III Bioenergetics
- Bioenergetics: The Role of ATP
- Biologic Oxidation 119
- The Respiratory Chain & Oxidative Phosphorylation 126
Section IV Metabolism of Carbohydrates
- Overview of Metabolism & the Provision of Metabolic Fuels 139
- Carbohydrates of Physiological Significance 152
- The Citric Acid Cycle: The Central Pathway of Carbohydrate, Lipid & Amino Acid Metabolism 161
- Glycolysis & the Oxidation of Pyruvate 168
- Metabolism of Glycogen 176
- Gluconeogenesis & the Control of Blood Glucose 185
- Pathways of Hexose Metabolism 196
Section V Metabolism of Lipids
- Lipids of Physiologic Significance 211
- Oxidation of Fatty Acids: Ketogenesis 223
- Biosynthesis of Fatty Acids & Eicosanoids 232
- Metabolism of Acylglycerols & Sphingolipids 245
- Lipid Transport & Storage 253
- Cholesterol Synthesis, Transport, & Excretion 266
Section VI Metabolism of Proteins & Amino Acids
- Biosynthesis of the Nutritionally Nonessential Amino Acids 281
- Catabolism of Proteins & of Amino Acid Nitrogen 287
- Catabolism of the Carbon Skeletons of Amino Acids 297
- Conversion of Amino Acids to Specialized Products 313
- Porphyrins & Bile Pigments 323
Section VII Structure, Function, & Replication of Informational Macromolecules
- Nucleotides 339
- Metabolism of Purine & Pyrimidine
- Nucleotides 347
- Nucleic Acid Structure & Function 359
- DNA Organization, Replication, & Repair 370
- RNA Synthesis, Processing, & Modification 394
- Protein Synthesis & the Genetic Code 413
- Regulation of Gene Expression 428
- Molecular Genetics, Recombinant DNA, & Genomic Technology 451
Section VIII Biochemistry of Extracellular & Intracellular Communication
- Membranes: Structure & Function 477
- The Diversity of the Endocrine
- System 498
- Hormone Action & Signal
- Transduction 518
Section IX Special Topics (A)
- Nutrition, Digestion, & Absorption 537
- Micronutrients: Vitamins & Minerals 546
- Free Radicals & Antioxidant Nutrients 564
- Glycoproteins 569
- Metabolism of Xenobiotics 583
- Clinical Biochemistry 589
Section X Special Topics (B)
- Intracellular Traffic & Sorting of Proteins 607
- The Extracellular Matrix 627
- Muscle & the Cytoskeleton 647
- Plasma Proteins & Immunoglobulins 668
- Red Blood Cells 689
- White Blood Cells 700
Section XI Special Topics (C)
- 55 Hemostasis & Thrombosis 711
- 56 Cancer: An Overview 722
- 57 Biochemical Case Histories 746
- 58 The Biochemistry of Aging 755
- The Answer Bank 771
- Index 777
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